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October 28, 2026CompoundingHHS lets 503A pharmacies compound six peptides under an interim enforcement discretion policyOctober 28, 2026Trial resultRetatrutide beats Ozempic on blood sugar and weight in head-to-head TRANSCEND-T2D-2 trialOctober 23, 2026FDA approvalFDA extends once-weekly insulin icodec (Awiqli) to children 10 and older with type 2 diabetesOctober 21, 2026CompoundingCitizen petition asks FDA not to allow compounding of seven peptides reviewed by its advisory committeeOctober 1, 2026Trial resultSurvodutide SYNCHRONIZE-2 phase 3 results in obesity with type 2 diabetes published in NEJMSeptember 30, 2026Trial resultEloraTZP (eloralintide plus tirzepatide) phase 2 results presented at EASD 2026September 30, 2026Trial resultOrforglipron ACHIEVE-4 cardiovascular safety trial published in The LancetSeptember 29, 2026Trial resultFull TRIUMPH-2 retatrutide results published in The LancetSeptember 24, 2026FDA approvalFDA approves insulin efsitora alfa (Onswik), a once-weekly basal insulin for type 2 diabetesSeptember 21, 2026WADAWADA publishes 2027 Prohibited List, naming peptides as examples of non-approved substances

October 28, 2026CompoundingHHS lets 503A pharmacies compound six peptides under an interim enforcement discretion policyOctober 28, 2026Trial resultRetatrutide beats Ozempic on blood sugar and weight in head-to-head TRANSCEND-T2D-2 trialOctober 23, 2026FDA approvalFDA extends once-weekly insulin icodec (Awiqli) to children 10 and older with type 2 diabetesOctober 21, 2026CompoundingCitizen petition asks FDA not to allow compounding of seven peptides reviewed by its advisory committeeOctober 1, 2026Trial resultSurvodutide SYNCHRONIZE-2 phase 3 results in obesity with type 2 diabetes published in NEJMSeptember 30, 2026Trial resultEloraTZP (eloralintide plus tirzepatide) phase 2 results presented at EASD 2026September 30, 2026Trial resultOrforglipron ACHIEVE-4 cardiovascular safety trial published in The LancetSeptember 29, 2026Trial resultFull TRIUMPH-2 retatrutide results published in The LancetSeptember 24, 2026FDA approvalFDA approves insulin efsitora alfa (Onswik), a once-weekly basal insulin for type 2 diabetesSeptember 21, 2026WADAWADA publishes 2027 Prohibited List, naming peptides as examples of non-approved substances

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Blend or stack

Tesamorelin + Ipamorelin

Combines an FDA-approved GHRH analog (tesamorelin, approved for HIV-associated belly fat) with an unapproved secretagogue.

What is in it

Growth hormone axisFDA-approvedFlashcard

Tesamorelin

Egrifta · Egrifta SV

Tesamorelin is a lab-made version of the body's growth-hormone-releasing hormone.

Growth hormone axisEarly human dataFlashcard

Ipamorelin

Ipamorelin acetate · NNC 26-0161

Ipamorelin is a small lab-made peptide (five building blocks) that copies the hunger hormone ghrelin to make the pituitary release growth hormone.

Is there evidence for the combination?

We found no published study of this pair. Tesamorelin's approval covers only its labeled use, taken alone.

Each ingredient at a glance

Ingredient	Evidence	US FDA status	Sports (WADA)
Tesamorelin	FDA-approved	FDA-approved (Egrifta, 2010; Egrifta SV; Egrifta WR, March 2025) for reducing excess abdominal fat in HIV-infected…	Prohibited at all times (S2.2.4 GHRH and analogues; named)
Ipamorelin	Early human data	Not FDA-approved	Prohibited at all times (S2.2.4 growth hormone secretagogues; named)

Mixing adds unknowns. A blend carries the risks of every ingredient, and the interactions are untested. Vial contents and ratios are set by sellers and are not standardized. See each ingredient page for safety and legal details.