Longevity & mitochondrial
Chonluten
Also called Khonluten, Honluten, Хонлутен, EDG peptide, Glu-Asp-Gly
Chonluten is a very short lab-made peptide (three amino acids) from Vladimir Khavinson's Russian 'peptide bioregulator' series, aimed at the lungs and airways. In Russia it is sold as a dietary supplement, not a medicine. The research is mostly cell studies, and good human trials are missing.
Overview
Chonluten is a very short lab-made peptide (three amino acids) from Vladimir Khavinson's Russian 'peptide bioregulator' series, aimed at the lungs and airways. In Russia it is sold as a dietary supplement, not a medicine. The research is mostly cell studies, and good human trials are missing.
How it works
Proposed, not established. Like the other Khavinson peptides, it is suggested to act on gene activity inside cells. In a human monocyte/macrophage cell line (THP-1) it increased programmed cell death of the monocytes, switched on the STAT1 signaling pathway, and lowered release of the inflammatory messengers TNF and IL-6 after a bacterial-toxin challenge 2. Whether this happens in the human body is unknown.
What research shows
- Cell study (THP-1 human monocytes/macrophages; Italian–Russian team including Khavinson, 2022): Chonluten reduced TNF and IL-6 release under inflammatory stimulation, roughly doubled monocyte apoptosis, and reduced monocyte sticking to activated blood-vessel cells 2.
- A 2020 review by the developers says it improved standard therapy in patients with chronic bronchitis with an asthmatic component, but gives no patient numbers or trial details 3.
- No controlled human trial with published data was found.
- Most work comes from the Khavinson group and its collaborators; independent replication is scarce.
Doses studied in people
No verified dose from a published controlled human trial; supplement-label directions are not trial data.
Read this first: these are the amounts given to participants in published studies or written on official prescribing labels, reported for reference. They are not recommendations. Trial doses were chosen for specific patients under medical supervision, and a dose that is safe in one person can be harmful in another.
Vial math
Many research vials hold 5 or 10 mg of powder. This table shows how much ends up in each mark on a U-100 insulin syringe for common amounts of added liquid. It is arithmetic only, not a dose.
| Vial | Liquid added | Concentration | Per unit (0.01 mL) | |
|---|---|---|---|---|
| 5 mg | 1 mL | 5 mg/mL | 50 mcg | Open in calculator |
| 5 mg | 2 mL | 2.5 mg/mL | 25 mcg | Open in calculator |
| 5 mg | 3 mL | 1.67 mg/mL | 16.7 mcg | Open in calculator |
| 10 mg | 1 mL | 10 mg/mL | 100 mcg | Open in calculator |
| 10 mg | 2 mL | 5 mg/mL | 50 mcg | Open in calculator |
| 10 mg | 3 mL | 3.33 mg/mL | 33.3 mcg | Open in calculator |
More sizes: all vial sizes · How this works: Syringes and units · Reconstitution guide.
Safety
- No formal human safety studies have been published; long-term safety is unknown.
- The Russian supplement entry lists hypersensitivity, pregnancy and breastfeeding as contraindications 4.
- Unregulated 'research' products sold elsewhere may vary in purity and content.
Report side effects of any drug or product to the FDA through MedWatch. For a possible poisoning in the US, call Poison Control at 1-800-222-1222.
Legal status
- FDA
- Not FDA-approved.
- Compounding
- Not listed in any category of FDA's 503A bulk drug substance nominations (list updated May 14, 2026), so it has no recognized route for US pharmacy compounding 5.
- Sports (WADA)
- Not named on the 2026 List. If it has no current government approval as a human medicine anywhere, it would fall under S0 (non-approved substances, prohibited at all times); Russian supplement registration is not a drug approval. Confirm with your anti-doping organization 6.
- Other
- Russia: registered as a dietary supplement (БАД), not as a medicine (certificate dated 08.02.2023) 4.
Rules change often. See Legal status of peptides for how these categories work.
History
Developed at the St. Petersburg Institute of Bioregulation and Gerontology 1. A Russian supplement product under the name Хонлутен (Chonluten) holds a 2023 dietary-supplement registration, owned by the company Garmonia 4.
Common questions
Is Chonluten a drug?
What does the evidence show?
Is Chonluten banned in sport?
It is not named on WADA's 2026 list, but non-approved substances generally fall under the S0 'prohibited at all times' rule 6.
What are the known risks?
Human safety has not been formally studied. The Russian supplement listing advises against use in pregnancy, breastfeeding or with hypersensitivity 4.
Related compounds
Bronchogen
AEDL peptide · Ala-Glu-Asp-Leu
Bronchogen is a tiny lab-made peptide, four amino acids long, from the Russian 'peptide bioregulator' program led by Vladimir Khavinson.
Vilon
KE dipeptide · Lys-Glu
Vilon is the smallest of Vladimir Khavinson's Russian 'peptide bioregulators': just two amino acids (lysine and glutamic acid).
Epitalon
epithalon · epithalone
Epitalon is a tiny four-amino-acid peptide made in the lab, modeled on an extract from the pineal gland.
Sources
- Khavinson VKh. Peptides, genome, aging. Advances in Gerontology 2014;4(4):337–345 (developer's review; Table 1 lists names, sequences and masses) Journal
- Avolio F et al. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line. Int J Mol Sci 2022;23(7):3607 Journal
- Khavinson V et al. Peptides: Prospects for Use in the Treatment of COVID-19. Molecules 2020;25(19):4389 PubMed review
- LS GEOTAR (Russian medicines reference): Хонлутен® (Chonluten) – dietary supplement entry, registration RU.77.99.88.003.R.000299.02.23 (08.02.2023) Regulatory
- FDA: Bulk Drug Substances Nominated for Use in Compounding Under Section 503A (updated May 14, 2026) Regulatory
- WADA 2026 Prohibited List (official English text, Dutch Treaty Series Trb. 2026, 25) Regulatory
Last reviewed 2026-10-26 · How we research · Found an error? See our corrections policy.