Longevity & mitochondrial
Ovagen
Also called EDL peptide, Glu-Asp-Leu, liver peptide bioregulator
Ovagen is a very short lab-made peptide (three amino acids) from Vladimir Khavinson's Russian 'peptide bioregulator' series; its developers list it as a liver regulator. Almost no detailed research on it has been published, even by the group that made it. Do not confuse it with a different veterinary product also called Ovagen, which is a fertility hormone for animals.
Overview
Ovagen is a very short lab-made peptide (three amino acids) from Vladimir Khavinson's Russian 'peptide bioregulator' series; its developers list it as a liver regulator. Almost no detailed research on it has been published, even by the group that made it. Do not confuse it with a different veterinary product also called Ovagen, which is a fertility hormone for animals.
How it works
Proposed, not established. The developers' 2021 review groups the EDL sequence with peptides said to act on gene activity, and reports that it influenced the p53 pathway in aging kidney cells in culture (together with another peptide, AED) 2. No liver-specific mechanism was found in the published literature reviewed.
What research shows
- Developer review (2021): the EDL peptide was reported to regulate p53 in a cell model of kidney-cell aging, alongside AED 2.
- No peer-reviewed animal or human studies specifically on Ovagen's liver effects were found in this review.
- All available information comes from Vladimir Khavinson's group; there is no independent replication.
Doses studied in people
No published human dosing data exist; doses circulating online are not trial-derived.
Read this first: these are the amounts given to participants in published studies or written on official prescribing labels, reported for reference. They are not recommendations. Trial doses were chosen for specific patients under medical supervision, and a dose that is safe in one person can be harmful in another.
Vial math
Many research vials hold 5 or 10 mg of powder. This table shows how much ends up in each mark on a U-100 insulin syringe for common amounts of added liquid. It is arithmetic only, not a dose.
| Vial | Liquid added | Concentration | Per unit (0.01 mL) | |
|---|---|---|---|---|
| 5 mg | 1 mL | 5 mg/mL | 50 mcg | Open in calculator |
| 5 mg | 2 mL | 2.5 mg/mL | 25 mcg | Open in calculator |
| 5 mg | 3 mL | 1.67 mg/mL | 16.7 mcg | Open in calculator |
| 10 mg | 1 mL | 10 mg/mL | 100 mcg | Open in calculator |
| 10 mg | 2 mL | 5 mg/mL | 50 mcg | Open in calculator |
| 10 mg | 3 mL | 3.33 mg/mL | 33.3 mcg | Open in calculator |
More sizes: all vial sizes · How this works: Syringes and units · Reconstitution guide.
Safety
- No human safety studies have been published; safety is unknown.
- Name confusion risk: 'Ovagen' is also the brand of a veterinary follicle-stimulating hormone product that FDA lists on an import alert for unapproved animal drugs 4.
- Unregulated 'research' products may vary in purity, sequence and content.
Report side effects of any drug or product to the FDA through MedWatch. For a possible poisoning in the US, call Poison Control at 1-800-222-1222.
Legal status
- FDA
- Not FDA-approved.
- Compounding
- Not listed in any category of FDA's 503A bulk drug substance nominations (list updated May 14, 2026), so it has no recognized route for US pharmacy compounding 5.
- Sports (WADA)
- Not named on the 2026 List. If it has no current government approval as a human medicine anywhere, it would fall under S0 (non-approved substances, prohibited at all times). Confirm with your anti-doping organization 6.
- Other
- A separate veterinary product named 'Ovagen' (an FSH hormone from New Zealand) appears on FDA Import Alert 68-19; it is unrelated to the peptide 4.
Rules change often. See Legal status of peptides for how these categories work.
History
Created at the St. Petersburg Institute of Bioregulation and Gerontology and listed in the institute's line of synthetic 'cytogen' peptides 13. Published studies naming Ovagen specifically are rare.
Common questions
Is Ovagen approved?
No. The peptide is not FDA-approved and has no recognized US compounding route 5.
What does the evidence show?
Is Ovagen the same as the animal fertility product?
No. A veterinary follicle-stimulating hormone sold as 'Ovagen' is a different product, listed by FDA on an import alert 4.
Is Ovagen banned in sport?
It is not named on WADA's 2026 list, but non-approved substances generally fall under S0, prohibited at all times 6.
Related compounds
Livagen
KEDA peptide · Lys-Glu-Asp-Ala
Livagen is a small lab-made peptide (four amino acids) from Vladimir Khavinson's Russian 'peptide bioregulator' series, named for the liver.
Chonluten
Khonluten · Honluten
Chonluten is a very short lab-made peptide (three amino acids) from Vladimir Khavinson's Russian 'peptide bioregulator' series, aimed at the lungs and airways.
Epitalon
epithalon · epithalone
Epitalon is a tiny four-amino-acid peptide made in the lab, modeled on an extract from the pineal gland.
Sources
- Khavinson VKh. Peptides, genome, aging. Advances in Gerontology 2014;4(4):337–345 (developer's review; Table 1 lists names, sequences and masses) Journal
- Khavinson VKh et al. Peptide Regulation of Gene Expression: A Systematic Review. Molecules 2021;26(22):7053 PubMed review
- St. Petersburg Institute of Bioregulation and Gerontology – institute overview (developer's own material, c. 2007) Regulatory
- FDA Import Alert 68-19: Detention without physical examination of unapproved finished new animal drugs (lists 'Ovagen – Follicle Stimulating Hormone', South Pacific Sera Ltd, New Zealand) Regulatory
- FDA: Bulk Drug Substances Nominated for Use in Compounding Under Section 503A (updated May 14, 2026) Regulatory
- WADA 2026 Prohibited List (official English text, Dutch Treaty Series Trb. 2026, 25) Regulatory
Last reviewed 2026-10-26 · How we research · Found an error? See our corrections policy.